If you’re into advanced skincare, you’ve probably seen the buzz around Salmon DNA (PDRN). It’s one of the hottest ingredients in Korean beauty right now, known for its ability to regenerate skin, improve elasticity, and restore that youthful glow. But not all Salmon DNA treatments are created equal.

Why Salmon DNA in the first place?

Salmon DNA has surged in popularity within the aesthetics industry due to its remarkable skin-rejuvenating properties. Rich in polynucleotides—natural building blocks of DNA—salmon DNA helps repair damaged skin, boost collagen production, and deeply hydrate the skin at a cellular level. This makes it especially effective in improving elasticity, reducing fine lines, and restoring a youthful glow. Its compatibility with human skin, low risk of allergic reaction, and regenerative benefits have made it a go-to ingredient in treatments like skin boosters and mesotherapy. As a result, salmon DNA is increasingly seen as a powerful, science-backed solution for those seeking natural and long-lasting skin revitalization.

There’s a big difference between in-office med spa treatments like Rejuran, Iluma Luna, and Crystal Rose and the at-home Medicube PDRN skincare line you can grab on Amazon.

Let’s break down the difference.

Rejuran: The OG Salmon DNA Treatment

Rejuran is one of the most popular Korean skin booster treatments and often called the “skin healer.” It has earned a stellar reputation in Korea for its unique ability to regenerate skin from within, rather than simply masking concerns—this is what really sets it apart. Rejuran Healer is built on highly purified polynucleotides (PN) derived from salmon DNA to repair damaged skin, boost elasticity, and smooth fine lines. When paired with microneedling or microneedling with radiofrequency, Rejuran goes deep to stimulate regeneration where it counts.

Best for: Fine lines, dullness, enlarged pores, acne scars, skin laxity, and anyone who wants noticeable anti-aging results with proven clinical research behind it.

Iluma Luna: Radiance Meets Renewal

Iluma Luna by Trubiologix is another skin booster product that blends polynucleotides (PN)—DNA-derived biomolecules, typically from salmon—with hyaluronic acid (HA) and peptides to support skin regeneration and rejuvenation, particularly in delicate areas like under the eyes. Iluma Luna claims to provide relatively high concentrations of PN combined with HA for hydration and gradual release of beneficial molecules, designed to smooth fine lines, brighten dark circles, reduce puffiness, and repair visible signs of skin damage. It’s a go-to choice for patients who want that healthy, luminous look with the bonus of elasticity and hydration.

Best for: Dull, uneven, or stressed skin that needs a radiant reset especially under the eyes

Crystal Rose: Hydration + Brightening

Crystal Rose is an advanced bio-revitalization ampoule formulation designed to improve skin tone, texture, hydration, and radiance. Loaded with key ingredients like hyaluronic acid, peptides, glutathione (a potent antioxidant), plus a full complex of supportive actives (amino acids, vitamins B, C, E, etc.), it works to stimulate fibroblasts, boost natural collagen and elastin production, neutralize free radicals, and deliver deep moisture so that dry, tired or aging skin appears smoother, firmer, more even, and more luminous. It is best mixed with Iluma Luna to provide brightening agents to improve both hydration and tone. It’s designed to give skin a plumper, fresher look with an emphasis on glow.

And here’s the bonus: TRU biologix doesn’t just stop at in-office treatments. They also have salmon DNA skincare such as Exoblanc PDRN Mask, Exoblanc Boosting Cream, and Exoblanc Spicule Cream, professional-grade skincare you can purchase in-office to extend and maintain your treatment results at home.

Best for: Anyone wanting an all-in-one solution for brightness, hydration, and ongoing maintenance with a linked skincare routine.

Medicube: Salmon DNA at Home

On the other side, you have Medicube, a Korean skincare line you can easily buy on Amazon. Their PDRN-infused products (like serums and creams) are gentle, hydrating, and great for everyday maintenance. Their product lines address a range of skin concerns — from acne, redness, enlarged pores, and sensitive skin to aging, dullness, and uneven tone.

Medicube’s at-home skincare and device line is designed to support and enhance the results of in-office treatments, not replace them. By improving skin hydration, elasticity, and absorption of active ingredients, Medicube helps maintain and prolong the benefits of professional procedures between visits. However, it is not a substitute for medical-grade interventions—rather, it works as a complementary step to keep skin healthy and optimized until the next appointment.

Best for: Daily skincare, barrier repair, and glow on a budget.

The Bottom Line

In-office treatments (Rejuran, Iluma Luna, Crystal Rose) are clinical-grade, more intensive, and deliver real regenerative results that can’t be matched by over-the-counter products.
Medicube is great for daily maintenance and keeping your skin hydrated and radiant, but it won’t deliver the same transformation as professional treatments.
If you want the best of both worlds: go to your med spa for treatments, and then support results at home with something like the Rejuran Medi line or Trubiologix’s Exoblanc skincare line.

A Quick Note on Promoitalia

While the focus here is on Korean brands, it’s worth mentioning that the Italian brand Promoitalia also carries advanced Salmon DNA treatments. Their protocols are highly recommended in med spas worldwide and another great option if you’re looking to explore beyond Korean skin boosters.

Korean Salmon DNA Treatments vs. At-Home Skincare